Human Intestinal Model Insights.
Field notes, data, and perspective on human gut biology from the scientists building RepliGut®. New thinking on absorption, inflammation, toxicity, and metabolic disease.
Human Intestinal Model Insights, Explained By The People Modeling It
This blog is where the Altis team shares human intestinal model insights you can put to work. We write about what the data actually shows, from oral absorption and metabolism to inflammation, safety, and gut hormones. Expect method notes, fresh results, and clear takes on where preclinical science is heading.
Every post ties back to real biology. We build human in vitro intestinal models and run custom CRO studies, so the writing here reflects work at the bench, not marketing theory. Regulators are moving the same way, as the FDA advances alternative methods. If you are moving past Caco-2, this is the thinking behind that shift.
Four Questions We Keep Coming Back To
Each topic maps to a program our clients run every day. Follow the one that fits your science.
DMPK & ADME
How oral drugs are absorbed, transported, and metabolized across the human gut, with biology Caco-2 cannot reproduce.
Read DMPK posts
Inflammatory Disease
IBD, immune-epithelial crosstalk, and testing therapies in human tissue where the disease actually lives.
Read inflammation posts
Toxicity & Safety
Catching GI toxicity early, on human cells, so safety risks surface long before they reach a patient.
Read toxicity posts
GLP-1 & Metabolic
Gut hormones, oral peptides, and the intestinal biology behind diabetes, obesity, and metabolic disease.
Read metabolic postsGet New RepliGut® Science In Your Inbox
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New human intestinal model insights, most recent first.
Why GI Toxicity Slips Through Preclinical Screening
Ask a program lead which toxicity they are most afraid of finding late, and the gut is rarely the first
Well-to-Well Consistency: Seeding, Confluence, and Real Signal vs Noise
Some of the most damaging variability in a gut assay never involves the drug at all. It lives between neighboring
Reproducibility in Your Hands: Why an Assay Drifts When It Moves Between Labs
A model can be perfectly reproducible in the lab that built it and still fall apart the moment it lands