Human Biology.
Humane Science.
Our vision: a world where science keeps its promise to patients.
Our mission: to make human biology the foundation of drug discovery.
We build RepliGut®, human intestinal models that show how a drug behaves in people. They read out human biology, not an animal or a decades-old cell line.
Most drugs fail in people. The models are part of the problem.
Nine out of ten drugs that enter clinical trials never reach patients. Too often they looked safe and effective in testing. That testing relied on animals or on cell lines that do not reflect real human biology.
The gut is where much of the trouble starts. It controls how oral drugs are absorbed, broken down, and tolerated. Yet researchers have lacked human intestinal models that are both accurate and easy to use.
Altis changes the starting point. We give scientists human-relevant data from the beginning, so fewer surprises show up later.
A New Approach, and the rules are catching up
Our platforms are New Approach Methodologies, or NAMs: human-relevant tests designed to reduce the reliance on animal studies. Regulators are actively encouraging the shift.
The FDA NAMs Roadmap and the FDA Modernization Act are opening the door to human models in preclinical research. Altis was built for exactly this moment. See the FDA on alternative methods.
Real human gut tissue, ready for the lab.
We start with ethically sourced human intestinal stem cells and grow them into working human gut tissue. You can access it as a ready-to-use product or as a custom study run by our scientists.
Source
Ethically sourced stem cells from real human donors, spanning multiple regions of the intestine and maintained in our own biobank.
Grow
Cells proliferate and differentiate into the cell types of the human gut epithelium, the same biology you are trying to predict.
Test
You get reproducible, physiologically relevant data for screening, disease modeling, absorption, and toxicity.
A need for better human intestinal models
Choosing the right model early decides whether a program succeeds. For the intestine, the usual options fall short. Caco-2 is a cancer line that misses real transporter and metabolic biology. Animal guts differ from ours.
RepliGut® reproduces the human intestinal epithelium region by region, from duodenum to colon, so your data reflects the tissue where the drug actually acts. Explore RepliGut® Planar
Three questions RepliGut answers better than Caco-2.
Absorption & metabolism
Predict how an oral drug is absorbed, transported, and metabolized in the human gut, using biology Caco-2 cannot reproduce.
In Vitro DMPKInflammatory disease
Model IBD and immune-epithelial interactions in human tissue to test how therapies act where the disease lives.
IBD modelsToxicity & safety
Screen for GI toxicity early, on human cells, so safety risks surface before they reach the clinic.
StemTox
Add immune cells with RepliGut® Immune Co-Culture
Much of human disease is driven by immune-epithelial cross-talk. RepliGut® Immune Co-Culture places human immune cells beneath the epithelium, so you can study that interaction directly.
Explore Immune Co-CultureBetter science that needs fewer animals.
Because RepliGut replicates human intestinal biology directly, it can reduce the number of studies that rely on animals, without giving up predictive power.
That is better for research and better for patients: clearer preclinical signals, stronger clinical trials, and less reliance on animal models across the pipeline.
Human biology first. That is the whole point.
Ready to build on human biology?
See how RepliGut® fits your program: kits, custom services, or a quick conversation with our team.