Capturing the Complexity of the Human Gut
Altis Biosystems has created a next-generation in vitro cell-based culture models of the intestinal epithelium for human relevant preclinical modeling of intestinal inflammation, toxicity, bioavailability, and barrier integrity
Through the replication of native human biology, our innovative intestinal stem cell platform delivers a wealth of physiologically relevant preclinical insights, ultimately enhancing the performance of clinical trials and diminishing the necessity for animal testing.
RepliGut® Systems
The RepliGut® model systems, derived from adult human donor stem cells, are designed to replicate the complex structure of the human small intestine and colonic epithelium using a standard user friendly format. These models offer a more biologically accurate approach to screening compounds, modeling diseases, and conducting microbiome research.
The RepliGut® model delivers valuable data insights, rapid screening capabilities, and an unparalleled biobank of ethically sourced donor intestinal cells, paving the way for more effective compound screening, disease modeling, and microbiome research.
Applications
Intestinal Barrier Function
Maintains barrier integrity with high TEER values
Inflammatory Response
Directly stimulate with proinflammatory cytokines for mechanistic insights
GI Toxicity
Screen compounds for drug-induced GI toxicity early
Intestinal Drug Disposition
More relevant metabolic activities than Caco-2 cells (cancer cells)