RepliGut® Planar models recreate the biology of the human intestine using a convenient membrane supported culture platform. These models represent the different regions of the intestine enabling physiologically relevant and translatable study of inflammation, toxicity, bioavailability, barrier integrity, and host-microbe interactions.
The standardized plate format with access to both apical and basal surfaces enables wide range of assays to suit your needs.
The RepliGut® Models are created using a biomimetic scaffold that not only supports the well-being of the cells but also provides a protective barrier, shielding them from the cassette's rigid semi-permeable membrane. This essential feature ensures the viability of the cells and enhances their overall functionality.
The innovative design of the RepliGut® Models incorporates apical and basal reservoirs, which enable compounds, additional cell types, and epithelial cells on both the basal and apical surfaces to interact effectively. This unique feature significantly expands research opportunities and fosters improved understanding of cellular processes.
The user-friendly design of RepliGut® Planar is highly advantageous for conducting a wider range of downstream assays, including imaging and barrier studies. In contrast to spherical organoids of varying sizes and shapes, RepliGut® Planar allows for convenient access to the apical surface of the epithelium, effectively enhancing the development of downstream assays.
The RepliGut® kits come in two convenient sizes, 12 or 96 wells, tailored to meet the specific needs of scientists. These comprehensive kits provide everything scientists require to cultivate cells within their own facility, featuring a precoated membrane support multiwell plate, region-specific stem cells, and culture media.
Unrivaled biobank with multiple donors, allows customers to choose regional specificity of the small intestine and colon from donors of different demographic backgrounds to further enhance study data. Fit-for-purpose specimens, aligned with scientific objectives, and the guaranteed ability to work with the same donor for years.
Different demographic backgrounds to further enhance study data
Ability to work with the same donor for years
Multiple regions available from small intestine and colon
Ethics Committee approved organ procurement