Altis Services

ALTIS BIOSYSTEMS

Platform

RepliGut® is a unique, human stem cell-derived platform that recreates the intestinal epithelium in a continuous layer of stem and differentiated cells. RepliGut® can be purchased as a product, or Altis Biosystems can provide the services you require.

The high throughput platform supports quick screening of thousands of candidates and fosters efficient development through reduced timelines and costs. Focus applications include preclinical studies for compound screening, investigating the effects of diseases, and microbiome research.

The RepliGut® Difference

Replicates human biology

Replicates human biology
to support development of safer, more effective drugs.

Decreased Animal-based Preclinical Studies

Reduces the need for animal-based preclinical studies for compound screening, disease modeling, and microbiome research.

Reduces downstream timelines

Reduces downstream timelines and costs involved in clinical trials by producing for effective drug candidates.

Accurate and Reproducible Data

More accurate and reproducible data as a basis for much better success rates in clinical trials and beyond.

Innovators, outsource research to Altis or buy RepliGut® kits

RepliGut® Planar

The monolayer format produces a continuous layer of stem or differentiated cells on a flat and porous surface.

platform_diagram1@2x

Each tissue sample on the patent-pending RepliGut® kit features a biomimetic scaffold, which separates RepliGut® cells from the cassette’s porous membrane and allows RepliGut® cells to survive for a prolonged period. Without the RepliGut® scaffold, stem cells cannot survive on the cassette.

Luminal and basal reservoirs allow compounds and additional cell types to interact with the epithelial cells for side specific assays.

RepliGut® Planar was developed to replace Caco-2 cells (cancer cells) and animals, which are currently used as a part of compound screening during preclinical studies, before human testing. This 2D monolayer platform should provide much better results than current methods, since it uses proliferative stem cells and terminally differentiated cells.

platform_img1@2x

RepliGut® Kit

The form factor for RepliGut® kit is a multiwell plate, which can be provided in 12 or 96 well sizes, depending on a scientist's needs. Each well contains a cassette insert with an individual tissue sample.

RepliGut® kits can be purchased with all the materials that scientists need to culture the cells in their own facility, including the transwell multiwell plate, stem cells and media.

RepliGut® Planar Tissue Sample

RepliGut® tissue constructs are polarized monolayers that express tight junction proteins and can be tailored to be comprised of stem/progenitor cells, differentiated cells, or both. All major cell lineages in physiologic ratios can be achieved.

Planar
SMALL INTESTINE Duodenum, Jejunum COLON Transverse

Multiple Donor Biobank

Unrivaled biobank with multiple donors, allows customers to choose regional specificity of the small intestine and colon from donors of different demographic backgrounds to further enhance study data. Fit-for-purpose specimens, aligned with scientific objectives, and the guaranteed ability to work with the same donor for years.

Different demographic backgrounds to further enhance study data

Different demographic backgrounds to further enhance study data

Guaranteed ability to work with the same donor for years

Guaranteed ability to work with the same donor for years

Multiple regions available from small intestine and colon

Multiple regions available from small intestine and colon

Access to primary cells and the crypts

Access to primary cells and the crypts

Fit-for-purpose specimens, aligned with scientific objectives

Fit-for-purpose specimens, aligned with scientific objectives

Ethics Committee approved organ procurement

Ethics Committee approved organ procurement

More platforms currently under development.
To purchase a RepliGut® Kit, please contact us.