Literature and Articles

Browse peer-reviewed literature, posters, webinars, blog articles, and more showing how we and others are using RepliGut Systems to support discovery.

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Manuscript: NSAID-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells
Poster: Characterization of biological variability in a stem cell-derived human intestinal epithelium model
Poster: Genomic evaluation of RepliGut Planar Jejunum in Response to metabolic Inducers
Poster Presented at ISSX/DMDG meeting – June 2023
Poster: Genomic evaluation of RepliGut Planar Jejunum in response to metabolic inducers
Inflammation

Scientist Jarrett Bilton, PhD recently travelled to the 25th North American ISSX conference in Boston. In collaboration with researchers at Genentech, RepliGut® Planar Jejunum was evaluated for gene expression patterns in response to prototypical metabolic inducers Rifampin, CITCO, 3-MC, and Calcitriol.

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Poster: Characterization of biological variability in a stem cell-derived human intestinal epithelium model
Inflammation

Associate Director Liz Boazak recently traveled to the 2nd MPS World Summit held in Berlin, Germany June 25-29, 2023.  Her poster was presented in the Reproducibility topic session and describes characterizing multiple donor and batch statistics of baseline RepliGut® Planar- transverse colon. 

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Poster: The Development of Human Primary Culture Systems to Model
Inflammation
Inflammatory Signaling in Crohn’s Disease and Ulcerative Colitis
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MiniReview: Modeling the Complex Human Intestinal Mucus - Microbiome Nexus In Vitro. 2024, March 28, Journal of Applied Microbiomics
Host-Microbe
Altis senior researcher Swetha Peddibhotla and other colleagues review the role of mucus in maintaining health and homeostasis in the gut
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Poster: Studying the Complex Intestinal Mucus – Microbiome Nexus Using Sterile Human Mucus Harvested from RepliGut® Planar. 
Host-Microbe, Inflammation
Presented by Swetha Peddibhotla at Translational Microbiome conference, Boston, MA, March 2024.
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Poster: A Novel Approach to Harvest Human Mucus on RepliGut® Planar Platform for Research Related to Gastrointestinal Tract and Its Associated Disorders, along with Drug Delivery Studies.
Host-Microbe, Inflammation
Presented by Swetha Peddibhotla at PharmSci 360 in Orlando Florida, November 2023
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Poster: Characterization of biological variability in a stem cell-derived human intestinal epithelium model
Inflammation
Associate Director Liz Boazak recently travelled to the 2nd MPS World Summit held in Berlin, Germany June 25-29, 2023. Her poster was presented in the Reproducibility topic session and describes characterizing multiple donor and batch statistics of baseline RepliGut® Planar- transverse colon. Poster further describes how minimizing the variability improves ability to discern true biological responses to inflammatory insults.
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Manuscript: Evaluation of human primary intestinal monolayers for drug metabolizing capabilities
ADME
In this 2019 manuscript, Dr. Jennifer Speer and colleagues describe levels of CYP3A4, UGTs 2B17, 1A1 and 1A10, and CES2 proteins in freshly isolated intestinal crypts compared to 2 different monolayer intestinal epithelium formats derived from intestinal crypt stem cells. this work highlights the importants of the mechanical properties of the cell scaffold in maintaining intestinal epithelial cell metabolic functionality.
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TLR Signaling in IBD Begins at the Epithelium
Species Differences in Drug Absorption: The 63% That Became 3%
Ester Prodrug Design for the Human Gut, Not the Cancer Line
How a Bad Esterase Profile Distorts BCS Classification
CES1 vs CES2: The Two Enzymes That Decide Carboxylesterase Drug Metabolism
What Caco-2 Gets Wrong About Prodrug Bioavailability
Anti-Drug Antibodies: The Quiet Tax on Every IBD Biologic
TL1A Beyond IBD: What Happens When a Gut Target Goes Systemic
Oral Drug Delivery in IBD: Why the Best New Drugs Still Come as Injections
TL1A Bispecifics: The Race to Break the IBD Efficacy Ceiling
TL1A in IBD: Why the Whole Field Suddenly Cares About One Ligand
Altis enters strategic partnership with CN-Bio
Poster: Characterization of a novel human primary intestinal epithelial monolayer platform in response to a cytokine challenge
How Does Altis Envision the Future of the Pharma Industry?
Manuscript: Analysis of Interleukin 8 Secretion by a Stem-Cell-Derived Human Intestinal Epithelial Monolayer Platform
Manuscript: Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells
Manuscript: Evaluation of human primary intestinal monolayers for drug metabolizing capabilities
Poster: Primary Human Small Intestine Monolayers For Assessing Drug-Induced Intestinal Liabilities In Vitro
Poster: A Sensitive and Specific Human Primary Stem Cell-Based In Vitro Assay for Predicting The Gastrointestinal Toxicity Risk of Therapeutic Agents
Poster: A primary jejunum and primary hepatocyte multi-organ MPS: a promising tool for more predictive studies of human drug ADME and oral bioavailability
Manuscript: NSAID-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells
Poster: Characterization of biological variability in a stem cell-derived human intestinal epithelium model
Poster: Genomic evaluation of RepliGut Planar Jejunum in Response to metabolic Inducers
How Does Altis Biosystems Envision the Future of the Pharma/Biopharma Industry?
Assessing Drug-induced Gut Toxicity In Vitro
Predicting Clinical GI Safety Outcomes Using an in vitro Human Intestinal Epithelial Model
Poster Presented at ISSX/DMDG meeting – June 2023

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