Literature and Articles
Ready to Go With Your Gut?
Literature
Inflammation
GI Toxicity
ADME
Host-Microbe
Poster: Genomic evaluation of RepliGut Planar Jejunum in response to metabolic inducers
Inflammation
Scientist Jarrett Bilton, PhD recently travelled to the 25th North American ISSX conference in Boston. In collaboration with researchers at Genentech, RepliGut® Planar Jejunum was evaluated for gene expression patterns in response to prototypical metabolic inducers Rifampin, CITCO, 3-MC, and Calcitriol.
Poster: Characterization of biological variability in a stem cell-derived human intestinal epithelium model
Inflammation
Associate Director Liz Boazak recently traveled to the 2nd MPS World Summit held in Berlin, Germany June 25-29, 2023. Her poster was presented in the Reproducibility topic session and describes characterizing multiple donor and batch statistics of baseline RepliGut® Planar- transverse colon.
Poster: The Development of Human Primary Culture Systems to Model
Inflammation
Inflammatory Signaling in Crohn’s Disease and Ulcerative Colitis
MiniReview: Modeling the Complex Human Intestinal Mucus - Microbiome Nexus In Vitro. 2024, March 28, Journal of Applied Microbiomics
Host-Microbe
Altis senior researcher Swetha Peddibhotla and other colleagues review the role of mucus in maintaining health and homeostasis in the gut
Poster: Studying the Complex Intestinal Mucus – Microbiome Nexus Using Sterile Human Mucus Harvested from RepliGut® Planar.
Host-Microbe, Inflammation
Presented by Swetha Peddibhotla at Translational Microbiome conference, Boston, MA, March 2024.
Poster: A Novel Approach to Harvest Human Mucus on RepliGut® Planar Platform for Research Related to Gastrointestinal Tract and Its Associated Disorders, along with Drug Delivery Studies.
Host-Microbe, Inflammation
Presented by Swetha Peddibhotla at PharmSci 360 in Orlando Florida, November 2023
Poster: Characterization of biological variability in a stem cell-derived human intestinal epithelium model
Inflammation
Associate Director Liz Boazak recently travelled to the 2nd MPS World Summit held in Berlin, Germany June 25-29, 2023. Her poster was presented in the Reproducibility topic session and describes characterizing multiple donor and batch statistics of baseline RepliGut® Planar- transverse colon. Poster further describes how minimizing the variability improves ability to discern true biological responses to inflammatory insults.
Manuscript: Evaluation of human primary intestinal monolayers for drug metabolizing capabilities
ADME
In this 2019 manuscript, Dr. Jennifer Speer and colleagues describe levels of CYP3A4, UGTs 2B17, 1A1 and 1A10, and CES2 proteins in freshly isolated intestinal crypts compared to 2 different monolayer intestinal epithelium formats derived from intestinal crypt stem cells. this work highlights the importants of the mechanical properties of the cell scaffold in maintaining intestinal epithelial cell metabolic functionality.
All
Blogs
Literature
Videos
Protocols
FAQ
Contact us to learn more about RepliGut® Model Kits and Services.
