September 18, 2023

Author Andrea Bhatt and colleagues used a monolayer of intestinal epithelial cells to show that exposure to NSAIDs at physiologically relevant doses can cause changes in permeability in the small intestine. This effectively creates an NSAID-induced leaky gut model. This article highlights the potential utility of RepliGut® Planar for assessing toxicity of dietary factors, bacterial metabolites, […]

Associate Director Liz Boazak recently traveled to the 2nd MPS World Summit held in Berlin, Germany June 25-29, 2023. Her stem cell intestinal model poster was presented in the Reproducibility topic session and describes characterizing multiple donor and batch statistics of baseline RepliGut® Planar- transverse colon.  Poster further describes how minimizing the variability improves the ability to

Scientist Jarrett Bilton, PhD, recently travelled to the 25th North American ISSX conference in Boston.  In collaboration with researchers at Genentech, RepliGut® Planar Jejunum was evaluated for gene expression patterns. The focus was on understanding how RepliGut Planar Jejunum responds to prototypical metabolic inducers Rifampin, CITCO, 3-MC, and Calcitriol.  The poster shows the suitability of