Supportive, Consultative Approach
Whether you know exactly what you want, or need our consultation, our PhD level project leads are there to help you use RepliGut® models to their fullest potential.
Efficient and effective project design guided by project leads with hands-on experience.
Full visibility to ongoing work with frequent communication.
High success rates with reliable timelines and consultation throughout.
Supportive environment of collaboration, a key ingredient to driving valuable, actionable insight.
Common Project Types
Intestinal Barrier Function
RepliGut® Models maintain barrier integrity with high TEER values. Compounds can be assessed for the potential to disrupt barrier function.
Dosing and sampling of inflammatory cytokines can be performed in either the apical or basal compartments.
GI toxicities are the most common adverse events during Phase 1 clinical trials. RepliGut® Models can be used to screen compounds for drug-induced GI toxicity early in the drug development process.
Intestinal Drug Disposition
RepliGut® Planar offer a remarkable capability to assess the absorption or release of compounds, in a format similar to Caco-2 cells, with added benefit of the ability to perform studies with cells derived from various regions of the small intestine and colon and in multiple donors
Unlike spherical organoids, RepliGut® Planar cultures directly enable access to both apical and basal surfaces independently. The models are sequentially stimulated to proliferate then differentiate which further enriches understanding of cell type involvement in each endpoint
Ethically sourced biobank consisting of multiple intestinal regions from multiple donors enabling both cross-region and cross-donor studies