Client Kristin Taylor Meadows and colleagues from Gossamer Bio used RepliGut® Planar to establish conditions for inducing inflammation response using TNFα. Using this model, they demonstrated GB004 protective effects, showing how GB-004, a novel compound in development for treating ulcerative colitis, can reduce the destructive effects of TNFα on epithelial barrier integrity.
Poster: GB004 Exhibits Protective Effects Directly on Epithelial Cells Using Ex Vivo Organoid and Monolayer Cultures
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- November 24, 2023
- Edited 6 months ago
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