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Increase Success in Drug Discovery While Reducing Time and Cost with RepliGut®

ABOUT US

Altis Biosystems has created a next-generation in vitro platform that reduces the time and cost of developing safer, more effective drugs.

By replicating native human biology, the stem cell platform produces more accurate and reproducible data for better clinical trial performance and reduces the need for animal testing.

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PLATFORM

The RepliGut® Platform

RepliGut® is a unique, stem cell derived platform that recreates the human small intestine and colonic epithelium for more biologically relevant screening of compounds, disease modeling, and microbiome research.

With a scalable platform, actionable data, high throughput screening to test thousands of compounds, and an unrivaled biobank, RepliGut® is the future of in vitro testing during drug development.

SERVICES

The RepliGut® is a reproducible and scalable platform that is suitable for studying many aspects of drug disposition including toxicity, metabolism, drug absorption, and efficacy.

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Intestinal Barrier Function

Maintains barrier integrity with high TEER values

Inflammatory Response

Inflammatory Response

Comprised of polarized intestinal cells grown on transwells

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GI Toxicity

Screen compounds for 
drug-induced GI toxicity early

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Intestinal Drug Disposition

Developed to replace Caco-2 cells (cancer cells) and animals

NEWS AND ARTICLES

December 23, 2020

How Does Altis Biosystems Envision the Future of the Pharma/Biopharma Industry?

There is a growing need to address the high failure rate of drug candidates as they progress through clinical trials. Altis Biosystems aims to bring its technological advances to the forefront, enabling the drug development process to more effectively translate results from preclinical experiments to late-stage clinical trials.

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November 30, 2020

Enhancing Human Gut Tissue Models through Gene Editing

The variety of normal and diseased human tissues needed to perform comprehensive screening of drug candidates is a key resource for next-generation preclinical models, but obtaining these tissues is challenging.

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DIGITAL EVENTS

January 21-24, 2021

Crohn's Colitis Congress


Book a Meeting

January 25-27, 2021

SLAS 2021 Digital International Conference and Exhibition


Book a Meeting

CONTACT US

Have a question? Want to stay informed about Altis, RepliGut, and more platforms currently under development? Send us a message!