About Us
Our vision is to transform preclinical therapeutic development with best-in-class human cell-based model systems and reduce reliance on animal models in discovery pipelines
Our Mission
At Altis Biosystems, our mission is to develop advanced cell-based assays that bridge the gap between preclinical research and clinical translation. We strive to provide researchers with reliable and predictive tools that accurately recapitulate human biology, enabling faster and more efficient drug discovery and development. Our goal is to create clinically translatable assays that accelerate the transition of promising therapies from the bench to the bedside, ultimately improving patient outcomes and reducing animal use in research.
Ready to Go With Your Gut?
Contact us to learn more about RepliGut® Model Kits and Services.
Our Mission
Altis’ mission is to provide scientific innovation, through collaborative relationships, by helping companies develop safer and more effective therapies to treat patients suffering from human disease. We support life science researchers by providing expertise and unique in vitro platforms to further their research and increase their understanding of human biology, while reducing the need for animal testing.
Customer Focused
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A need for better models
In order to successfully advance a novel therapy through the drug development pipeline, it is crucial to select an appropriate model system early on. Model systems provide us with valuable insights into disease mechanisms and enable effective evaluation of potential treatments. However, the current lack of user-friendly pre-clinical pharmacological testing models for the human intestine significantly hinders our ability to develop new therapies for intestinal disorders. Additionally, it presents a challenge in ensuring the safe passage of orally administered treatments for other conditions through the gut without unwanted side effects.
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World class service
Pioneering Technology
Altis Biosystems has pioneered the creation of Repligut® Systems, a collection of in vitro models derived from stem cells and designed specifically for pre-clinical drug discovery. These innovative systems overcome the constraints of conventional cell lines and animal models, providing a highly accurate representation of human intestinal physiology.
Harnessing the power of stem cells
Our flagship RepliGut® Planar models advance novel pharmaceuticals by harnessing the potential of human donor intestinal stem cells. These cells undergo a process of sequential proliferation and differentiation, ultimately transforming into the essential cell types found in the human gastrointestinal epithelium for use in drug discovery and development.
The RepliGut® model delivers valuable data insights, rapid screening capabilities, and an unparalleled biobank of ethically sourced donor intestinal cells, paving the way for more effective compound screening, disease modeling, and microbiome research.
Customer Focused
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Reducing the need for animal models
Our RepliGut® Models, which accurately replicate the complex cellular lifecycle of the intestinal crypt, provide an exceptional platform for numerous applications. Derived from various regions of the intestine, they allow for compound screening, disease modeling, drug disposition analysis, toxicity assessments, efficacy studies, and fundamental research investigations. With their human-derived physiologically-relevant capabilities, our models have the power to vastly reduce the dependence on animal studies, in line with the transforming landscape of pre-clinical drug discovery.
Smiles guaranteed
World class service
Ready to Go With Your Gut?
Contact us to learn more about RepliGut® Model Kits and Services.
